PRO 2000

PRO 2000
Systematic (IUPAC) name
2-naphthalenesulfonic acid, sodium salt, polymer with formaldehyde
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 29321-75-3
ATC code  ?
Chemical data
Formula (C10H8O3S.CH2O.Na)x
Mol. mass Approximately 5 kD

PRO 2000 is the name of an experimental vaginal microbicide which has been proposed as a preventative medicine for reducing the risk of contracting HIV. It has never been recommended as an effective medicine to be used for any purpose. Some clinical trials have shown that under some conditions it may provide some protection against HIV.

History

Endo Pharmaceuticals manufactures the drug.[1]

Efficacy

Animal testing studies done on macaques have shown that PRO 2000 is effective in preventing the transmission of HIV. Other studies have given supportive evidence that the product is safe in humans and would be an appropriate candidate for testing.[2]

One study of 9385 women in sub-Saharan Africa showed that PRO 2000 was not effective in preventing HIV.[3]

References

  1. ^ "AIDSinfo - HIV/AIDS Drug Information - PRO 2000". aidsinfo.nih.gov. 2011 [last update]. http://www.aidsinfo.nih.gov/DrugsNew/DrugDetailNT.aspx?int_id=330. Retrieved 20 November 2011. 
  2. ^ Patton, D. L.; Cosgrove Sweeney, Y. T.; Paul, K. J. (2008). "A Summary of Preclinical Topical Microbicide Vaginal Safety and Chlamydial Efficacy Evaluations in a Pigtailed Macaque Model". Sexually Transmitted Diseases 35 (10): 889–897. doi:10.1097/OLQ.0b013e31817dfdb8. PMID 18607310.  edit
  3. ^ McCormack, S.; Ramjee, G.; Kamali, A.; Rees, H.; Crook, A. M.; Gafos, M.; Jentsch, U.; Pool, R. et al. (2010). "PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): A phase 3, randomised, double-blind, parallel-group trial". The Lancet 376 (9749): 1329. doi:10.1016/S0140-6736(10)61086-0.  edit
types
products
Organizations
Clinical trials